Conjugating biologically active molecules with polymers, high molecular weight non- immunogenic and lipophilic compounds has been described to improve in vivo profiles of the biologically active molecules. The invention relates to a conjugate comprising a polymer, a biologically active molecule and cyclitol linking the polymer to the biologically active molecule. The invention also relates to an activated polymer composition comprising a polymer, an active functional group and a cyclitol linking the polymer to the active functional group.
申请公布号
WO2007016380(A2)
申请公布日期
2007.02.08
申请号
WO2006US29503
申请日期
2006.07.27
申请人
(OSI) EYETECH, INC.;TURNER, DAVID, I.;CALIAS, PERRY;COOK, GARY, P.;SHIMA, DAVID, T.
发明人
TURNER, DAVID, I.;CALIAS, PERRY;COOK, GARY, P.;SHIMA, DAVID, T.