MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS

摘要

Compounds of the formula (I), and N-oxides, salts, and stereoisomers thereof wherein A is OR¹, NHS(=O)_PR²; wherein; R¹ is hydrogen, C₁-C₆alkyl, C₀-C₃alkylenecarbocyclyl, C₀-C₃alkylene-heterocyclyl; R² is C₁-C₆alkyl, C₀-C₃alkylenecarbocyclyl, C₀-C₃alkyleneheterocyclyl; p is independently 1 or 2; n is 3, 4, 5 or 6; ---- deonotes an optional double bond; L is N or CRz; Rz is H or forms a double bond with the asterisked carbon; Rq is H or when L is CRz, Rq can also be C₁-C₆alkyl; Rr is quinazolinyl, optionally substituted with one two or three substituents each independently selected from C₁-C₆ alkyl, C₁-C₆alkoxy, hydroxyl, halo, haloC₁-C₆alkyl, amino, mono- or dialkylamino, mono- or dialkylaminocarbonyl, C₁-C₆alkyl- carbonylamino, C₀-C₃alkylenecarbocyclyl and C₀-C₃ alkyleneheterocyclyl; R⁵ is hydrogen, C₁-C₆alkyl, C₁-C₆alkoxyC₁-C₆alkyl or C₃-C₇cycloalkyl; R⁶ is hydrogen, C₁-C₆alkyl, C₁-C₆alkoxy, C₀-C₃alkylenecarbocyclyl, C₀-C₃alkyleneheterocyclyl, hydroxy, bromo, chloro or fluoro have utility in the treatment or prophylaxis of flaviviral infections such as HCV.