METHODS AND MEANS FOR USE IN DIAGNOSTICS AND TREATMENT OF DIABETES
摘要
The present invention identifies novel epitopes from the insulin B chain which is embodied in methods and means for diagnostics and treatment of type 1 diabetes. The epitopes were found in a peptide comprising a fragment of the human insulin B chain. Using HLA-A2 tetramers having the peptide of the invention cytotoxic T-cells were found in peripheral blood cells samples from healthy individuals. The invention demonstrates that these autoreactive CTL directed against insulin B chain are able to destroy insulin producing beta-cells. Moreover, a significant proportion of cytotoxic T-cells from islet transplant recipients with recurrent autoimmunity and loss of insulin production recognized this peptide or analogue thereof. The peptide has a high affinity for the HLA-A2 allele, in particular HLA-A*0201. Based on the novel epitopes according to the invention, diagnostic and therapeutic methods and medicaments for the prevention or treatment of type 1 diabetes are provided.
申请公布号
WO2006132530(A3)
申请公布日期
2007.02.01
申请号
WO2006NL50017
申请日期
2006.01.30
申请人
LEIDEN UNIVERSITY MEDICAL CENTER;DRIJFHOUT, JAN, WOUTER;ROEP, BART, OTTO