发明名称 |
Immunocytokine sequences and uses thereof |
摘要 |
The invention provides a family of antibodies that specifically bind the human cell surface glycosphingolipid GD2. The antibodies comprise modified variable regions, more specially, modified framework regions, which reduce their immunogenicity when administered to a human. The antibodies may be coupled to a therapeutic agent and used in the treatment of cancer.
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申请公布号 |
US7169904(B2) |
申请公布日期 |
2007.01.30 |
申请号 |
US20030737208 |
申请日期 |
2003.12.16 |
申请人 |
EMD LEXIGEN RESEARCH CENTER CORP. |
发明人 |
GILLIES STEPHEN D.;LO KIN-MING;QIAN SUSAN X. |
分类号 |
C07K16/00;A61K48/00;C07K16/30;C07K16/46;C12N15/13 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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