METHOD FOR PREPARING 4ß-AMINO-4'-DEMETHYL-4-DESOXYPODOPHYLLOTOXIN

摘要

The invention relates to a method for synthesizing 4ß-amino-4'-démethyl-4-desoxypodophyllotoxin of formula (1), characterized by comprising the following successive steps: a) reacting, in a pure weak acid or in a mixture consisting of acid, water and of organic solvent, without another solvent, at a temperature higher than the ambient temperature, thiourea with 4ß-halogenoacetamido-4'-demethyl-4-desoxypodophyllotoxin, and; b) recovering the 4ß-amino-4'-demethyl-4-desoxypodophyllotoxin.