摘要 |
<p>A process for the preparation of 2-[2-(4-Dibenzo[b,f] [l,4] thiazepin-11-yl-1- ?iperazinyl)ethoxy] ethanol fumarate commonly known as Quetiapine hemifumarate. Dibenzo[b,f] [l,4] thiazepin-11-[10H]one is halogenated with a halogenating agent in the ratio of 1 : 0.5 to 3 w/v in an organic solvent in the presence of an organic base at reflux temperature followed by condensation of the reaction with piperazine without isolating the imino chloride. The piperazinyl-dibenzo[b,f] [l,4] thiazepine is converted to Quetiapine hemifumarate which is purified by crystallization with alcohol at reflux temperature and precipitated it by cooling the reaction mixture and recovered by filtration.</p> |
申请人 |
USV LIMITED;TARUR, VENKATASUBRAMANIAN, RADHAKRISHNAN;SATHE, DHANANJAY, GOVIND;NAIDU, AVINASH, VENKATRAMAN;AHER, UMESH, PARASHRAM;PATIL , SACHIN, SHIVAJI |
发明人 |
TARUR, VENKATASUBRAMANIAN, RADHAKRISHNAN;SATHE, DHANANJAY, GOVIND;NAIDU, AVINASH, VENKATRAMAN;AHER, UMESH, PARASHRAM;PATIL , SACHIN, SHIVAJI |