PARTICLES FOR IMMUNOASSAYS AND METHODS FOR TREATING THE SAME

摘要

A method of treating particles to be used in immunoassays reduces interference in particle agglutination assays. For particles having covalent ly bound antibodies and residual NHS-ester or sNHS-ester groups on the surface, the reactive esters are treated with an aqueous mixture containing an amine compound of formula (I): H2N - R - X (I) The moiety -X is -NH2, -OH, or -CO2CH2CH3; and R is an alkyl group or a n alkyl ether group. When -X is -NH2 or -CO2CH2CH3, R contains from 1 to 20 carbon atoms; and when -X is -OH, R contains from 4 to 20 carbon atoms.