A DIRECT DRUG DELIVERY SYSTEM BASED ON THERMALLY RESPONSIVE BIOPOLYMERS
摘要
A method for delivering a drug depot of a compound of interest to a selected region in a subject. The method comprises administering a composition directly to said region of interest, the composition comprising the compound of interest to be delivered (such as an antiinflammatory agent or a chemotherapeutic agent) and a polymer (such as an elastin-like peptide or ELP) that undergoes an inverse temperature phase transition, so that a sustained release of the compound of interest at the selected region is provided. Compositions useful for carrying out the invention are also described.
申请公布号
WO2007002362(A2)
申请公布日期
2007.01.04
申请号
WO2006US24427
申请日期
2006.06.21
申请人
DUKE UNIVERSITY;SETTON, LORI A.;CHILKOTI, ASHUTOSH;KRAUS, VIRGINIA B.;BETRE, HELAWE;DREHER, MATTHEW R.
发明人
SETTON, LORI A.;CHILKOTI, ASHUTOSH;KRAUS, VIRGINIA B.;BETRE, HELAWE;DREHER, MATTHEW R.