PACKAGING SYSTEMS FOR HUMAN RECOMBINANT ADENOVIRUS TO BE USED IN GENE THERAPY

摘要

PROBLEM TO BE SOLVED: To provide improved methods and products based on adenovirus materials advantageously usable in gene therapy.

SOLUTION: Disclosed is a cell which is derived from human embryonic retinoblasts (HER) and contains a nucleic acid in which a nucleic acid encoding adenovirus E1A, E1B 21 kDa and E1B 55kDa gene products encodes adenovirus E1A, E1B 21kDa and E1B 55kDa gene products comprising nucleotides 459-3510 of a human adenovirus 5 (Ad5) genome and contains no pIX sequence.

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