METHOD OF TREATING A SOLID TUMOR DISEASE COMPRISING ADMINISTERING A COMBINATION COMPRISING IMATINIB AND AN INHIBITOR OF AN EFFLUX PUMP ACTIVE AT THE BLOOD BRAIN BARRIER OR DEMETHYL IMATINIB

摘要

The invention relates to a method of treating a warm-blooded animal having a solid tumor disease comprising administering a combination which comprises: a) a N-phenyl-2- pyrimidine-amine derivative, especially N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]- 2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine, b) at least one compound inhibiting the efflux pump active at the blood brain barrier selected from MDR1 and MRP2, c) optionally an antineoplastic agent, especially as defined herein, d) optionally an alkylating agent and e) optionally, hydroxyurea; to the use of such a combination for the preparation of a medicament for the treatment of a solid tumor disease; and to a commercial package or product comprising such a combination together with instructions for the treatment of a solid tumor disease. In a further aspect, the present invention pertains to a combination which comprises: a) optionally a N-phenyl-2-pyrimidine-amine derivative, especially N-{5-[4-(4- methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine (STI571 ), b) N-{5-[4-(piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2- pyrimidine-amine (CGP74588), c) optionally an antineoplastic agent, d) optionally an alkylating agent and e) optionally, hydroxyurea; to the use of such a combination for the preparation of a medicament for the treatment of a solid tumor disease; and to a commercial package or product comprising such a combination together with instructions for the treatment of a solid tumor disease.