| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide new peptides given from edible meat which is situated in an important position among foods and having hypotensive action or angiotensin I converting enzyme inhibiting activity, and to provide a pharmaceutical composition containing the peptides as an active ingredient. <P>SOLUTION: A peptide composition containing a pentapeptide having a structure of Ile-Arg-Val-Val-Glu and tripepides having structures of Val-Trp-Ile, Val-Gly-Arg, and Ile-Lys-Ile is obtained by hydrolyzing a protein of the edible meat, or myosin or actin of which the each is an important protein of the edible meat by action of a protease, such as Amano S (trade name). The peptides have the angiotensin I converting enzyme inhibiting activity and the hypotensive action, so as to be used as an angiotensin I converting enzyme inhibitor. Further, the peptides are highly safe and applied to a food for preventing hypertension and ameliorating a symptom thereof. <P>COPYRIGHT: (C)2007,JPO&INPIT |
