发明名称 |
INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE |
摘要 |
The present invention relates to compounds of formula: (I) or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection and to processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.
|
申请公布号 |
KR20060130027(A) |
申请公布日期 |
2006.12.18 |
申请号 |
KR20067006901 |
申请日期 |
2006.04.10 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
COTTRELL KEVIN M.;PERNI ROBERT B.;PITLIK JANOS |
分类号 |
C07C275/06;A61K38/05;A61K38/07;A61K38/08;C07D207/327;C07K5/06;C07K5/08;C07K5/10;C07K7/06 |
主分类号 |
C07C275/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|