QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS

摘要

The present invention relates to the use of a compound for the manufacture of a medicament for the treatment of a bacterial infection, said compound being a compound of formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof or a N-oxide form thereof, wherein R¹ is hydrogen, halo, polyhaloC_1-6alkyl, C_1-6alkyl, hydroxyC_1-6alkyl, C_1-6alkyloxy, Ar or Het; p is an integer equal to 1 or 2; R² is C_1-6alkyloxy, C_1-6alkyloxyC_1-6alkyloxy or C_1-6alkylt hio ; R³ is C_1-6alkyl, Ar, Het or Het1; R⁴ and R⁵ each independently are hydrogen, C_1-6alkyl or benzyl; or R⁴ and R⁵ together and including the N to which they are attached may form a radical selected from the group of pyrrolidinyl, 2-pyrrolinyl, 3-pyrrolinyl, pyrrolyl, imidazolidinyl, pyrazolidinyl, 2-imidazolinyl, 2-pyrazolinyl, imidazolyl, pyrazolyl, triazolyl, piperidinyl, pyridinyl, piperazinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, morpholinyl and thiomorpholinyl, each of said rings may optionally be substituted with C1-6alkyl, halo, polyhaloC_1-6alkyl, hydroxy, hydroxyC_1-6alkyl, C_1-6alkyloxy, amino, mono- or di(C_1-6alkyl)amino, C_1-6alkylt hio, C_1-6alkyloxyC_1-6alkyl, C_1-6alkylt hioC_1-6alkyl or pyrimidinyl; R⁶ is hydrogen, halo, polyhaloC_1-6alkyl, C_1-6alkyl, C_1-6alkylo xy, C_1-6alkylt hio ; or two vicinal R⁶ radicals may be taken together to form a bivalent radical of formula -CH=CH-CH=CH- ; r is an integer equal to 1 or 2; R⁷ is hydrogen, C_1-6alkyl, Ar, Het or Het1; provided that the bacterial infection is other than a Mycobacterial infection.