| 摘要 |
A method for fabricating an adhesiveless microfluidic device using solvent assisted thermal welding is provided. The method comprises use of a plurality of device layers of a bulk chemical conformation composition having a glass transition temperature that can be disrupted by a disrupting agent without total solvation, wherein the plurality of device layers when assembled define a plurality of defined component features. The device layers are immersed into the disrupting agent for a time period sufficient to disrupt the glass transition temperature of a defined depth of the surfaces of the device layers prior to their removal from the disrupting agent. The plurality of device layers are assembled and registered by contacting the plurality of device layer surfaces to form the defined component features. Pressure and heat are simultaneously applied to bring the assembly to a temperature below the pressure-specific, glass transition temperature of the bulk chemical conformation composition; but above the pressure-specific, glass transition temperature of the disrupted surface layer of the composition, for a time period sufficient to affect a weld between the contacted surfaces of the plurality of device layers. The temperature of the assembly is reduced over a time period sufficient to anneal the contacted surfaces of the plurality of device layers to form the microfluidic device.
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