The present invention is based on the discovery that Matrilin-1 has antiangiogenic and anticancer properties. The invention is directed to a method of treating a disease that responds to an inhibition of angiogenesis. Additionally, the invention can be applied to those at risk for developing a disease that responds to an inhibition of angiogenesis. The methods comprise administering to a mammal an effective angiogenesis-inhibiting amount of an Matrilin-1 consisting of Matrilin-1, Matrilin-1 fragment, analog, or derivative that is administered in a composition substantially free of other cartilage proteins.
申请公布号
WO2006128179(A2)
申请公布日期
2006.11.30
申请号
WO2006US20932
申请日期
2006.05.30
申请人
CHILDREN'S MEDICAL CENTER CORPORATION;MOSES, MARSHA, A.;FORADORI, MATTHEW, J.;LANGER, ROBERT, S.
发明人
MOSES, MARSHA, A.;FORADORI, MATTHEW, J.;LANGER, ROBERT, S.