PARAMAGNETIC METAL POLYAMINO COMPLEXES FOR MRI VISUALIZATION OF INTERNALIZED POLYNUCLEOTIDES

摘要

The invention relates to paramagnetic ion-based contrast agents that are positively charged at physiological pH and that bind non covalently to a polynucleotide chain for use in the preparation of a diagnostic formulation for the "in vivo" visualization of polynucleotides internalized into human or animal body cells by use of Magnetic Resonance Imaging techniques.