摘要 |
Methods for testing and assessing whether an agent that inhibits cdk activity produces a therapeutic response in a mammal, with a focus on detecting the inhibition of phosphorylation of the retinoblastoma protein (Rb) at putative phosphorylation sites, are disclosed. Also disclosed are methods for monitoring pharmacodynamic drug action of a cdk inhibitor in a surrogate tissue(s) of a mammal, preferably a rat, mouse or human.
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