发明名称 |
Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use |
摘要 |
The invention provides a butyrylcholinesterase variant having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acid. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition with the invention variant.
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申请公布号 |
US2006263345(A1) |
申请公布日期 |
2006.11.23 |
申请号 |
US20050549006 |
申请日期 |
2005.09.14 |
申请人 |
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发明人 |
WATKINS JEFFRY D.;PANCOOK JAMES D. |
分类号 |
A61K38/46;C07H21/04;C12N9/18;C12P21/06 |
主分类号 |
A61K38/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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