STABILIZED AMLODIPINE MALEATE FORMATIONS

摘要

The present invention provides improved, more stable formulations of amlodipine maleate where the formulations comprise from none to a minimal amount of magnesium. Such stable formulations show decreased production of the impurity amlodipine aspartate. Accordingly, the present invention provides formulations of amlodipine maleate comprising lubricants such as sodium stearyl furmarate, dimeticone, macrogol 6000, hydrogenated castor oil, and stearic acid. Methods of making and using the improved formulations are also provided.