The present invention relates to a method for promoting osteogenesis by contacting osteoblast progenitor cells with an LXR agonist. Said method is useful for the treatment or prevention of an imbalance in bone homeostasis in a subject using bone homeostasis-promoting compositions comprising an effective osteogenic stimulating amount of an LXR agonist in admixture with a pharmaceutically acceptable carrier. A further aspect is a method to produce bone tissue in vitro by contacting an LXR agonist with a population of osteoblast progenitor cells on a substrate, for a time sufficient to stimulate the generation of a matrix of bone tissue.
申请公布号
WO2006000577(A3)
申请公布日期
2006.11.09
申请号
WO2005EP52971
申请日期
2005.06.24
申请人
GALAPAGOS GENOMICS N.V.;VAN ROMPAEY, LUC;TOMME, PETER, HERWIG, MARIA