METHOD AND SYSTEM FOR ESTIMATING GENE EXPRESSION DATA

摘要

A method and system are provided for measuring differential gene expression that is induced on multiple experimental subjects or samples by controlled, multiple experimental factors, measured using microarrays or other devices that measure the activity of multiple probes per gene. The information in the readings made from all the probes in the microarrays or other devices that received the experimental samples is extracted simultaneously, without prior summarization or aggregation at the gene level, by employing a multi-factor model that explicitly accounts for differences in expression between genes, between probes from the same gene, and between the effects of the experimental factors.