发明名称 |
CATIONIC LIPIDS FOR THE TRANSFECTION OF NUCLEIC ACIDS |
摘要 |
The present invention relates to cationic lipids capable of forming complexes with nucleic acids and the use thereof for the transfection of eukaryotic cells. The cationic lipids according to the invention have general formulas (I) and (Ia): (see formulas (I) and (Ia), wherein E is a heteroaryl; Rl and R2 are selected from H, -R7-NH<SUB>2</SUB>, -CH-NH-NH<SUB>2</SUB>, alkyl; R7 is selected from alkyl, alkenyl, aryl, (C<SUB>1</SUB>-C<SUB>20</SUB>) alkyl-aryl- (C<SUB>0</SUB>-C<SUB>20</SUB>) alkyl; R3 and R4 are selected from: H, -R8-SH, -R8-NH-NH<SUB>2</SUB>/ -R8-CO-R9 or - R8-NH<SUB>2</SUB>; R8 is selected from: alkyl, alkenyl, aryl, (C<SUB>1</SUB>- C<SUB>20</SUB>) alkyl-aryl- (C<SUB>0</SUB> -C<SUB>20</SUB> ) alkyl; R9 is selected from: H, alkyl; R5 and R6 are selected from: H, alkyl, alkenyl, aryl, (C<SUB>1</SUB>-C<SUB>20</SUB>) alkyl-aryl. |
申请公布号 |
WO2006087752(A3) |
申请公布日期 |
2006.11.02 |
申请号 |
WO2006IT00072 |
申请日期 |
2006.02.13 |
申请人 |
POLITECNICO DI MILANO;ZANDA, MATTEO;BRUCHE, LUCA;FRIGERIO, MASSIMO;VIANI, FIORENZA;CHIAMENTI, LUCA;PANZERI, WALTER;ZAFFARONI, NADIA;FOLINI, MARCO;GRECO, MARIA ANGELA |
发明人 |
ZANDA, MATTEO;BRUCHE, LUCA;FRIGERIO, MASSIMO;VIANI, FIORENZA;CHIAMENTI, LUCA;PANZERI, WALTER;ZAFFARONI, NADIA;FOLINI, MARCO;GRECO, MARIA ANGELA |
分类号 |
C07D251/54;A61K31/53;C12N15/00 |
主分类号 |
C07D251/54 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|