发明名称 |
SYSTEMS AND METHODS FOR TREATING HUMAN INFLAMMATORY AND PROLIFERATIVE DISEASES, WITH A COMPOUND THAT PROVIDES FATTY ACID METABOLISM AND GLYCOLYSIS INHIBITION |
摘要 |
<p>The invention generally relates to systems and methods for treating inflammatory and proliferative diseases, enabling treatment of MDR tumor cells by using a bifunctional compound that inhibits both fatty acid metabolism and glycolysis. Thus, the invention links a fatty acid metabolism inhibitor to a glycolysis inhibitor. More particularly, the invention provides novel bifunctional compounds that link a moiety having the functionality of an oxirane carboxylic acid compound to a moiety having the functionality a glucose derivative. In specific embodiments, the invention provides a bifunctional compound that links a moiety having the functionality of etomoxir to a moiety having the functionality of 2-deoxy-D-glucose.</p> |
申请公布号 |
WO2006116217(A2) |
申请公布日期 |
2006.11.02 |
申请号 |
WO2006US15308 |
申请日期 |
2006.04.20 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF COLORADO;NEWELL, KAREN, ROGERS, M. |
发明人 |
NEWELL, KAREN, ROGERS, M. |
分类号 |
A61K31/7028 |
主分类号 |
A61K31/7028 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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