INTACT IGFBP-3 AS A COLON CANCER RISK FACTOR IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE

摘要

The subject invention provides a method for determining whether a human subject afflicted with long-lasting irritable bowel disease (IBD) has an increased risk fo'r developing colon cancer comprising: (a) determining the concentration of intact IGFBP-3 in a suitable cell-free bodily fluid sample taken from the subject; and (b) determining whether the concentration of intact IGFBP-3 determined in step (a) is indicative of an increased risk of colon cancer in a human subject afflicted with long- lasting IBD. This invention also provides a kit for performing the instant method.