| 摘要 |
Peptide is disclosed which is capable of binding to beta-strand in a separate peptide-containing molecule to form beta-sheet, wherein said peptide is selectively Nalpha-substituted in one edge (first) of the beta-strand-forming section of said peptide while the other edge (second) in the opposite orientation to the first edge in view of peptide backbone plane remains Nalpha-unsubstituted. Such the Nalpha-substituted peptide is capable of preventing association of said peptide with other beta-strand (target) but permits interaction of said peptide with target beta-strand in separate peptide-containing molecules through the Nalpha-unsubstituted edge.
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