发明名称 |
Polymer-modified synthetic proteins |
摘要 |
The present invention relates to methods and compositions for modifying peptides, polypeptides and proteins with polymers, especially glyco-mimetic polymers, so as to improve their biological activity or pharmacokinetic properties. The invention further provides methods and uses for such polymer-modified peptides, polypeptides and proteins. The invention is particularly suitable for use in the synthesis of polymer-modified synthetic bioactive proteins (FIG. 1 D), and of pharmaceutical compositions that contain such proteins.
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申请公布号 |
US7118737(B2) |
申请公布日期 |
2006.10.10 |
申请号 |
US20030332385 |
申请日期 |
2003.01.08 |
申请人 |
AMYLIN PHARMACEUTICALS, INC. |
发明人 |
KOCHENDOERFER GERD G.;BOTTI PAOLO;BRADBURNE JAMES A.;CHEN SHIAH-YUN;CRESSMAN SONYA;HUNTER CHRISTIE L.;KENT STEPHEN B. H.;LOW DONALD W.;WILKEN JILL G. |
分类号 |
A61K38/16;A61K38/17;C07K1/107;C07K1/113;C07K14/00;C07K14/435;C07K14/52;C12P21/02 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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