PROGNOSTIC METHOD FOR VASCULAR DISEASES

摘要

The present invention is directed to a group of genes and genetic polymorphisms that can be used to screen for individuals who are at high risk of developing a vascular disease, disorder or condition, such as cranio-vascular disease, including vascular occlusion, and overt stroke. The method comprises analysis of at least one marker in at least one of the genes of ADCY9 (NMJ)Ol 116); ANXA2 (NMJ)Ol 002858); BMP6 (NM_001718); CCL2 (NM_002982); CSF2 (NM_000758); ECEl (NM_001397 or its transcription variant NMJ 82918); ERG (NM_004449); MET (NM_000245); SELP (NM_003005); TEK (NM_000459); and TGFBR3 (NM_003243. When 5 or fewer of the genes are included in the analysis, it is preferable that one includes markers for at least SELP or BMP6 in the analysis. The invention is further directed to methods of predicting individuals at risk of specific diseases or disorders in a population using nucleic acid polymorphisms and Bayesian network analysis.