Microfluidic devices and methods of using microfluidic devices

摘要

Microfluidic devices (100), systems and methods of their use are provided. A microfluidic device (100) includes: a housing; a serpentine channel (212) disposed in the housing; and a set of resonant tunnelling electrodes disposed in the serpentine channel (212), wherein the microfluidic device (100) is configured to detect an analyte with the set of resonant tunnelling electrodes. A method for sequencing an analyte includes: aligning the analyte in a serpentine channel (212) that is disposed in a microfluidic device (100); and detecting the analyte with a set of resonant tunnelling electrodes. A system includes: a sample preparation device (120); and a detection device (140) including a serpentine channel (212) in fluid communication with the sample preparation device and a set of resonant tunnelling electrodes disposed in the serpentine channel, wherein the system is configured to detect an analyte with a set of resonant tunnelling electrodes.