| 摘要 |
The invention relates to a method for the synthesis of galanthamifle, the derivatives and analogues thereof of formula (1) where R<SUB>1</SUB>=a hydrogen atom. R<SUB>2</SUB>=a hydroxy group, R<SUB>1 </SUB>and R<SUB>2 </SUB>together form -O, R<SUB>3</SUB>, R<SUB>4</SUB>, and R<SUB>5 </SUB>independently=a hydrogen atom, a hydroxy group or a (C<SUB>1</SUB>-C<SUB>2</SUB>)alkoxy group, R<SUB>6</SUB>-H, (C<SUB>1</SUB>-C<SUB>12</SUB>)alkyl, (CH<SUB>2</SUB>)<SUB>n</SUB>NR<SUB>7</SUB>R<SUB>8</SUB>, or -(CH<SUB>2</SUB>)<SUB>n</SUB>N'R<SUB>7</SUB>R<SUB>8</SUB>R<SUB>9 </SUB>where n=1 to 12, Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a -SO, -SO<SUB>2</SUB>, or -NR<SUB>6 </SUB>group where R<SUB>6 </SUB>is as defined above or is an amine protecting group
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