发明名称 Aqueous dispersion comprising stable nanoparticles of a water-insoluble pyrrole carboxamide and excipient like middle chain triglycerides
摘要 A process for the preparation of a stable dispersion of solid particles, in an aqueous medium comprising combining (a) a first solution comprising a substantially water-insoluble substance which is a pyrrole carboxamide compound of Formula I, a water-miscible organic solvent and an inhibitor with (b) an aqueous phase comprising water and optionally a stabiliser, thereby precipitating solid particles comprising the inhibitor and the substantially water-insoluble substance; and optionally removing the water-miscible organic solvent; wherein the inhibitor is a non-polymeric hydrophobic organic compound as defined in the description. Also claimed are stable dispersions prepared by the process, solid particles prepared by the process and use of such particles.
申请公布号 US2006198893(A1) 申请公布日期 2006.09.07
申请号 US20050543545 申请日期 2005.07.27
申请人 ASTRAZENECA AB 发明人 LINDFORS LENNART
分类号 A61K31/454;A61K9/14;A61K31/401;A61K31/4015;C07D207/40;C07D207/416 主分类号 A61K31/454
代理机构 代理人
主权项
地址