发明名称 |
ИНГИБИТОРЫ СЕРИНОВЫХ ПРОТЕАЗ, В ЧАСТНОСТИ, НС-3-НС4А ПРОТЕАЗЫ |
摘要 |
The present invention relates to compounds of formula I or formula Ia or pharmaceutically acceptable salts thereof, that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are useful as antiviral agents. The invention further relates to pharmaceutically acceptable compositions comprising said compounds either for ex vivo use or for administration to a patient suffering from HCV infection and processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a pharmaceutical composition comprising a compound of this invention. |
申请公布号 |
RU2006105002(A) |
申请公布日期 |
2006.08.27 |
申请号 |
RU20060105002 |
申请日期 |
2004.07.16 |
申请人 |
ВЕРТЕКС ФАРМАСЬЮТИКАЛЗ ИНКОРПОРЕЙТЕД (US) |
发明人 |
БРИТТ Шон Д. (US);КОТТРЕЛЛ Кевин М. (US);ПЕРНИ Роберт Б. (US);ПИТЛИК Янош (US) |
分类号 |
C07K5/10;A61P31/12;C07K7/06 |
主分类号 |
C07K5/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|