METHODS AND COMPOSITIONS FOR IMPAIRING MULTIPLICATION OF HIV-1

摘要

A single isolated antibody or antibody fragment thereof binds to multiple variant sequences within an epitope of HIV-I Tat protein displayed in multiple strains and subtypes of HIV-I. This "pan-epitope" antibody is useful in therapeutic and prophylactic compositions and treatments of HIV-I infection, regardless of strain. This pan-epitope antibody is useful in assays for the detection of levels of HIV-I based on a measurement of the amount of Tat protein in a biological sample.