发明名称 |
Implant improving local bone formation |
摘要 |
A bone implant comprises an active agent on at least a portion thereof. The active agent is locally deliverable to bone proximate the implant in at least a two-phased release scheme. A first phase rapidly releases a first quantity of the active agent, and at least a second phase gradually releases a second quantity of the active agent, whereby bone formation stimulated by the active agent is modulated. In one embodiment, a porous implant comprises a porous portion coated with a calcium phosphate compound and which is contacted with a bisphosphonate compound to form a bisphosphonate layer chemically bound to the calcium phosphate at the surface of the porous portion and to form bisphosphonate molecules being non-chemically attached inside the pores of the porous portion. The non-chemically attached bisphosphonate molecules are released in the subject at a rate greater than that of the chemically bound bisphosphonate layer.
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申请公布号 |
US2006188542(A1) |
申请公布日期 |
2006.08.24 |
申请号 |
US20050061745 |
申请日期 |
2005.02.22 |
申请人 |
BOBYN JOHN D;TANZER MICHAEL |
发明人 |
BOBYN JOHN D.;TANZER MICHAEL |
分类号 |
A61F2/00;A61K31/663;A61K31/675 |
主分类号 |
A61F2/00 |
代理机构 |
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主权项 |
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地址 |
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