PIPERAZINE DERIVATIVES

摘要

The present invention relates to a crystalline form of 5-{(1S)-2-[(2R)-4-benzoyl-2-methyl-piperazin-1-yl]-1-methyl-2-oxo-ethoxy}-4-methoxy-pyridine-2-carboxylic acid methylamide, processes for the preparation thereof, compositions containing the crystalline form, and uses of the crystalline form. 5-{(1S)-2-[(2R)-4-Benzoyl-2-methyl-piperazin-1-yl]-1-methyl-2-oxo-ethoxy}-4-methoxy-pyridine-2-carboxylic acid methylamide is particularly suitable as a drug substance and inhibits the interaction of gp120 with CD4 and is therefore of use in the treatment of HIV, a retroviral infection genetically related to HIV, or AIDS.