发明名称 |
SYNTHESIS OF INHIBITORS OF P90RSK |
摘要 |
<p>The synthesis of the naturally occurring kaempferol glycoside SLO1O1-1, as well as analogs thereof, has been accomplished, as has its biochemical evaluation. SLO1O1-1 exhibits selective and potent p90 Rsk inhibitory activity at nanomolar concentrations without inhibiting the function of upstream kinases such as MEK, Raf, or PKC. The synthetic scheme of the invention verified the structural assignment of the natural product and has provided access to material sufficient for detailed biological evaluation.</p> |
申请公布号 |
WO2006086103(A2) |
申请公布日期 |
2006.08.17 |
申请号 |
WO2006US00709 |
申请日期 |
2006.01.10 |
申请人 |
UNIVERSITY OF VIRGINIA PATENT FOUNDATION;HECHT, SIDNEY, M.;MALONEY, DAVID |
发明人 |
HECHT, SIDNEY, M.;MALONEY, DAVID |
分类号 |
A61K31/7048 |
主分类号 |
A61K31/7048 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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