PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS

摘要

The present invention relates to novel acetic acid derivatives as peroxisome proliferator activated receptor (PPAR) modulators. Compounds described herein can be useful to inhibit or prevent diabetes or diabetes associated complications including, for example, Type II diabetes (T2DM), hyperglycemia, dyslipidemia, hypertension, coronary heart disease, cardiovascular disease, atherosclerosis, nephropathy, glomerulonephritis, glomerularsclerosis, nephrotic syndrome, hypertensive nephrosclerosis, polycystic ovarian syndrome, psoriasis, obesity, or eating disorders. Such compounds can also be useful to improve cognitive functions in dementia, as well as aldose reductase inhibitors. The invention also relates to pharmacological compositions comprising compounds described herein, as well as methods of treating diabetes or diabetes associated complications by administering such compound.