METHOD FOR DETECTING P53 DYSFUNCTION, METHOD FOR MOLECULAR DIAGNOSIS OF CANCER AND METHOD FOR EVALUATING COMPOUND EFFECTIVE IN TREATING CANCER

摘要

Detection of p53 dysfunction or molecular diagnosis of cancer is carried out by a method comprising the steps of measuring the expression level of at least one gene selected from the group consisting of CARS, MOCOS, TNFRSF9, LOC56901 and GEF-H1 or a gene which is functionally equivalent to the gene in a test tissue or a test cell; comparing the expression level of the gene with that of a corresponding gene in a normal tissue or a normal cell; and determining whether or not the expression level of the gene in the test tissue or the test cell is significantly higher than that of the corresponding gene in the normal tissue or the normal cell based on the comparison result. According to the method for molecular diagnosis of the present invention, regardless of the presence of p53 mutation or without directly detecting p53 mutation, it becomes possible to detect p53 dysfunction or to diagnose cancer caused by p53 dysfunction.