TRICYCLIC-SUBSTITUTED PYRAZOLYL BENZENESULFONAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF

摘要

The present invention is concerned with tricyclic-substituted pyrazolyl benzenesulfonamides of Formula I (See formula I) wherein R1 is phenyl substituted at position 4 with sulfamyl; wherein R2 is selected from C1-C6-haloalkyl, cyano, carboxyl, C1-C6-alkoxycarbonyl, C1-C6-carboxyalkyl, aminocarbonyl, C1-C6-N-alkylaminocarbonyl, N-arylaminocarbonyl, C1-C6-N,N- dialkylaminocarbonyl, C1-C6-N-alkyl-N-arylaminocarbonyl, C3-C7- cycloalkylaminocarbonyl, and C1-C6-hydroxyalkyl; wherein R3 and R4 together form (See formula II) wherein m is 2; wherein A is selected from phenyl and five membered heteroaryl; and wherein R6 is one or more radicals selected from halo, C1- C10-alkyl, C1-C6-alkylsulfonyl, C1-C6-haloalkyl, C1-C6-alkoxy, amino an d nitro; wherein aryl wherever occuring means phenyl, naphthyl, tetrahydronaphthyl, indane, biphenyl; or a pharmaceutically-acceptable salt thereof.