发明名称 |
GENETIC SELECTION OF SMALL MOLECULE MODULATORS OF PROTEIN-PROTEIN INTERACTIONS |
摘要 |
The present invention provides a method of production and screening of small molecule modulation of inter-macromolecule interaction. The method involves providing a living cell containing a gene that directs expression of a gene product to be assayed for the ability to modulate inter-macromolecule interactions and an inter-macromolecule interaction whose interaction can be monitored. The inter-macromolecule interaction is monitored in the living cell to determine if the inter-macromolecule interaction is modulated in the living cell relative to another, otherwise similar living cell that lacks said gene product.
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申请公布号 |
WO2006034431(A3) |
申请公布日期 |
2006.07.27 |
申请号 |
WO2005US34087 |
申请日期 |
2005.09.22 |
申请人 |
THE PENN STATE RESEARCH FOUNDATION |
发明人 |
BENKOVIC, STEPHEN, J.;HORSWILL, ALEXANDER, R.;SAVINOV, SERGEY |
分类号 |
C12Q1/00;C12N1/00;C12N5/00 |
主分类号 |
C12Q1/00 |
代理机构 |
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