发明名称 |
STRUCTURE-BASED RECEPTOR MIMICS TARGETED AGAINST BACTERIAL SUPERANTIGEN TOXINS |
摘要 |
The invention provides therapeutic compositions useful in the treatment of bacterial superantigen mediated conditions, such as Toxic Shock Syndrome. The compositions comprise genetically engineered bifunctional polypeptides containing a specific T-cell receptor binding domain and a specific MHC class II receptor binding domain, each targeting non-overlapping epitopes on a superantigen molecule against which they are designed. The anti-superantigen "receptor mimetics" or "chimeras" are rationally designed to recreate the modality of superantigen binding directly to both the TCR and the MHC-II receptor, and are capable of acting as decoys for superantigen binding, effectively out-competing the host T-cell and MHC-II receptors, the natural host receptors. |
申请公布号 |
WO2005120562(A3) |
申请公布日期 |
2006.07.20 |
申请号 |
WO2004US43138 |
申请日期 |
2004.12.23 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
GUPTA, GOUTAM;HONG-GELLER, ELIZABETH;SHIFLETT, PATRICK, R.;LEHNERT, NANCY, M. |
分类号 |
C07K1/00;A61K38/00;A61K39/00;A61K39/02;C07K14/31;C07K14/725;C07K14/74 |
主分类号 |
C07K1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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