摘要 |
The present invention provides compounds of Formula: (I); or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R3, and ring B are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same. |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;CORTE, JAMES, R.;QUAN, MIMI, L.;SMALLHEER, JOANNE, M.;PINTO, DONALD, J. |
发明人 |
CORTE, JAMES, R.;QUAN, MIMI, L.;SMALLHEER, JOANNE, M.;PINTO, DONALD, J. |