BISPECIFIC MOLECULE COMPRISING A LIGAND FOR A CELL-SURFACE PROTEIN AND A LIGAND FOR A T-CELL SURFACE PROTEIN

摘要

The present invention provides bispecific therapeutic molecules that target both aberrant cells, such as cancer cells, as well as T cells, and compositions comprising them. The invention further provides methods of detecting aberrant cells and methods of treating subjects with one or more cancers. The bi-specific molecules of the invention bind to both the T cells and the target aberrant cells, causing them to be brought into close proximity such that the effects of the T cell can be easily localized to the target aberrant cell.