发明名称 |
STABILIZED BIODEGRADABLE NEUROTOXIN IMPLANTS |
摘要 |
Biodegradable neurotoxin implants and methods of malting and using such implants are provided. Biodegradable neurotoxin implants include a neurotoxin, a biodegradable polymer component, and an acidity regulating component. The biodegradable polymer component is effective in controlling the release of the neurotoxin from the implant when the implant is located in a patient's body. The acidity regulating component is effective in maintaining a pH of the implant in a desired range that may be effective in stabilizing the neurotoxin as the implant biodegrades when the implant is located in a patient's body. In one embodiment, an implant includes a botulinum toxin, a biodegradable polymer, and either monomers from which a biodegradable polymer is derived or oligomers including monomeric units substantially identical to a monomer from which a biodegradable polymer is derived, or a combination of such monomers and oligomers. The oligomers and biodegradable polymer may be derived from a single type of monomer. The implants disclosed herein may be administered to a human or animal patient in which a therapeutic effect is desired for prolonged periods of time. |
申请公布号 |
WO2006036202(A3) |
申请公布日期 |
2006.07.06 |
申请号 |
WO2005US12121 |
申请日期 |
2005.04.08 |
申请人 |
ALLERGAN, INC.;HUGHES, PATRICK;OLEJNIK, OREST |
发明人 |
HUGHES, PATRICK;OLEJNIK, OREST |
分类号 |
A61L31/16;A61K39/02;A61K39/08;A61L31/06 |
主分类号 |
A61L31/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|