发明名称 |
COMPOSITIONS AND METHODS FOR DISRUPTION OF BRCA2-RAD51 INTERACTION |
摘要 |
Contemplated compounds disrupt interaction between BRCA2 and RAD51, likely by binding to RAD51. Based on the crucial role of the BRCA2-RAD51 complex formation in DNA repair and the role of RAD51 in the control of entry into S-phase from G1, numerous compositions and methods are presented. Among other advantageous uses, contemplated compounds may be employed as protective agents for non-neoplastic cells in chemotherapy before exposure of the cells to a chemotherapeutic drug, and/or as DNA-damage sensitizer for neoplastic cells. |
申请公布号 |
WO2006044933(A3) |
申请公布日期 |
2006.07.06 |
申请号 |
WO2005US37513 |
申请日期 |
2005.10.19 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;LEE, WEN-HWA;CHEN, PHANG-LANG;ZHU, JIEWEN |
发明人 |
LEE, WEN-HWA;CHEN, PHANG-LANG;ZHU, JIEWEN |
分类号 |
A61K31/4725;A61P35/00 |
主分类号 |
A61K31/4725 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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