发明名称 |
Methods of making pro-urokinase mutants |
摘要 |
Methods are provided for producing non-glycosylated, single-chain and two-chain pro-urokinase (pro-UK) mutants. The methods include cultivating a specific E. coli type B strain that has been transformed with specific plasmids carrying a cDNA sequence that encodes pro-UK mutants and carries specific promoter sequences. Products produced by the methods have medical use for thrombolysis performed while sparing hemostatic clots, e.g., for particular applications such as after a stroke or heart attack.
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申请公布号 |
US7070958(B2) |
申请公布日期 |
2006.07.04 |
申请号 |
US20040826598 |
申请日期 |
2004.04.16 |
申请人 |
THROMBOLYTIC SCIENCE, INC. |
发明人 |
SARMIENTOS PAOLO;PAGANI MASSIMILIANO |
分类号 |
C12P21/06;C07H21/04;C12N9/72;C12P21/02 |
主分类号 |
C12P21/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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