4-(经取代之环烷基甲基)咪唑-2-硫酮,4-(经取代之环烯基甲基)咪唑-2-硫酮,4-(经取代之环烷基甲基)-咪唑-2-酮,4-(经取代之环烯基甲基)-咪唑-2-酮及相关化合4-(SUBSTITUTED CYCLOALKYLMETHYL) IMIDAZOLE-2-THIONES, 4-(SUBSTITUTED CYCLOALKENYLMETHYL) IMIDAZOLE-2-THIONES, 4-( SUBSTITUTED CYCLOALKYLMETHYL) IMIDAZOL-2-ONES, 4-(SUBSTITUTED CYCLOALKENYLMETHYL) IMIDAZOL-2-ONES AND RELATED COMPOUNDS 4-(SUBSTITUTED CYCLOALKYLMETHYL) IMIDAZOLE-2-THIONES, 4-( SUBSTITUTED CYCLOALKENYLMETHYL) IMIDAZOLE-2-THIONES, 4-( SUBSTITUTED CYCLOALKYLMETHYL) IMIDAZOL-2-ONES, 4-(SUBSTITUTED CYCLOALKENYLMETHYL) IMIDAZOL-2-ONES AND RELATED COMPOUNDS

摘要

本发明揭示下式之化合物，094130573-p01.bmp其中^*表示一不对称碳，该化合物对α2B肾上腺素能受体之特异性超过对α2A及α2C肾上腺素能受体之特异性，并因此不具有或仅具有最小的心血管及／或镇静活性。该化合物可在包括人类之哺乳动物中作为医药用于治疗对α2B肾上腺素能受体激动剂治疗具有响应的疾病或减轻此类病况。094130573-p01.bmp