| 摘要 |
THE PRESENT INVENTION OF COMPOUNDS OF FORMULA (I)A STEREOCHEMICALLY ISOMERIC FORM THEREOF, AN - OXIDE FORM THEREOF OR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF, WHEREIN ALK¹ IS C₁-6 ALKANEDIYL OPTIONALLY SUBSTITUTED WITH HYDROXY, C₁-₄ ALKYLOXY OR C₁-₄ ALKYLCARBONYLOXY; -Z¹-Z²- IS A BIVALENT RADICAL; R¹, R² AND R³ ARE EACH INDEPENDENTLY SELECTED FROM HYDROGEN, C₁-6 ALKYL, HYDROXY,HALO AND THE LIKE; OR WHEN R¹ AND R² ARE ON ADJACENT CARBON ATOMS, R¹ AND R² TAKEN TOGETHER MAY FORM A BIVALENT RADICAL; R⁴ IS HYDROGEN OR C₁-6 ALKYL; A IS A BIVALENT RADICAL OF FORMULA -NR6- ALK²-(B-1), OR -NPIPERIDINYL-(CH₂)M (B-2) WHEREIN M IS 0 OR 1; R5 IS A RADICAL OF FORMULAWHEREIN N IS 1 OR 2; P¹ IS 0, AND P² IS 1 OR 2; OR P¹ IS 1 OR 2, AND P² IS 0; X IS OXYGEN, SULFUR OR =NR9; Y IS OXYGEN OR SULFUR; R7 IS HYDROGEN, C₁-6 ALKYL, C₃-6 CYCLOALKYL, PHENYL OR PHENYLMETHYL; R8 IS C₁-6 ALKYL, C₃-6 CYCLOALKYL PHENYL OR PHENYLMETHYL; R9 IS CYANO, C₁-6 ALKYL; C₃-6 CYCLO-ALKYL, C₁-6 ALKYLOXYCARBONYL OR AMINOCARBONYL; R10 IS HYDROGEN OR C₁-6 ALKYL; AND Q IS A BIVALENT RADIACAL. PROCESSES FOR PREPARING SAID PRODUCTS, FORMULATIONS COMPRISING SAID PRODUCTS AND THEIR USE AS A MEDICINE ARE DISCLOSED, IN PARTICULAR FOR TREATING CONDITIONS WHICH ARE RELATED TO IMPAIRED FUNDIC RELAXATION.
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