Cyclic hydroxylamine as psychoactive compounds

摘要

A compound of formula (I): in which X represents O or CH₂; R³ and R⁴ each independently represent hydrogen or C_1-6 alkyl; p represent 0 or 1; and R represents a five- or six-membered saturated or unsaturated ring selected from: formula (II), (III) and (IV); or R represents a five- or six-membered oxo-substituted unsaturated ring selected from: (V) and (VI); wherein R¹ and R² together represent an oxo group, or R¹ and R² each represent hydrogen, methoxy or ethoxy, or R¹ and R² together with the interjacent carbon atom represent a 1,3-dioxolane or 1,3-dioxane ring, attached via the 2 position and optionally bearing one or more methyl or ethyl groups; or a salt thereof, is suitable for the treatment of anxiety and depression.