Inhibitors of matrix metalloproteinase

摘要

Compounds of formula (I): wherein R¹ represents optionally substituted C_4-12 alkyl, optionally substituted C_2-6alkylaryl, or optionally substituted 5- or 6-membered aryl or heteroaryl; Z represents a bond, CH₂, O, S, SO, SO₂, NR⁴, OCR⁴R⁵, CR⁴R⁵O, or Z, R¹ and Q together form an optionally substituted fused tricyclic group; Q represents an optionally substituted 5- or 6-membered aryl or heteroaryl ring; X represents COR³ or N(OR⁸)COR⁹; R² represents SO₂R¹⁰ or SO₂NR¹⁰R¹¹; R³ represents OR⁶, NR⁶R⁷ or NR⁶OH; R⁴ and R⁵ each independently represents H, C_1-6 alkyl or C_1-4 alkylaryl; R⁶ and R⁷ each independently represents H, C_1-6 alkyl, or C_1-6 alkyl substituted with one or more heteroaryl groups, or R⁶ and R⁷ together with the nitrogen atom to which they are attached form a 5- or 6-membered ring which may optionally include 1 or more further heteroatoms selected from O, S and N; R⁸ and R⁹ each independently represents H or C_1-6 alkyl; R¹⁰ and R¹¹ each independently represents H or C_1-6 alkyl; and and physiologically functional derivatives thereof, with the exception of N-(ethoxycarbonyl)-N-[4-(1H-tetrazol-1-yl)phenyl]glycine, processes for their preparation, pharmaceutical formulations containing them and their use as inhibitors of matrix metalloproteinase enzymes (MMPs) are described.