Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives

摘要

The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R¹ and R² taken together form a bivalent radical of formula wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C_1-6alkyl; R³ is hydrogen or halo; R⁴ is hydrogen or C_1-6alkyl; R⁵ is hydrogen or C_1-6alkyl; L is C_3-6cycloalkyl, C_5-6cycloalkanone, C_2-6alkenyl, or L is a radical of formula -Alk-R⁶-, Alk-X-R⁷, -Alk-Y-C(-O)-R⁹, or -Alk-Y-C(-O)-NR¹¹R¹² wherein each Alk is C_1-12alkanediyl; and R⁶ is hydrogen, cyano, C_1-6alkylsulfonylamino, C_3-6cycloalkyl, C_5-6cycloalkanone, or a heterocyclic ringsystem; R⁷ is hydrogen, C_1-6alkyl, hydroxyC_1-6alkyl, C_3-6cycloalkyl, or a heterocyclic ringsystem; X is O, S, SO₂ or NR⁸; said R⁸ being hydrogen or C_1-6alkyl; R⁹ is hydrogen, C_1-6alkyl, C_3-6cycloalkyl, C_1-6alkyloxy or hydroxy; Y is NR¹⁰ or a direct bond; said R¹⁰ being hydrogen, or C_1-6alkyl; R¹¹ and R¹² each independently are hydrogen, C_1-6alkyl, C_3-6cycloalkyl, or R¹¹and R¹² combined with the nitrogen atom may form an optionally substituted pyrrolidinyl, piperidinyl, piperazinyl or 4-morpholinyl ring. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impairment of gastric emptying.